Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 17/20 | 1.00 |
| ▸ | NPC1 | O15118 | 15/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 13/20 | 1.00 |
| ▸ | MAPT | P10636 | 13/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | PKM | P14618 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251987 | 0.92 | RAB9A (0.85) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL28090799 | 0.90 | RAB9A (0.83) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL30828596 | 0.88 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL8769429 | 0.88 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL2565238 | 0.86 | HDAC8 (0.76) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL8769840 | 0.86 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL8770201 | 0.86 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL3142490 | 0.85 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL18470910 | 0.85 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL532678 | 0.85 | MAPT (0.74) | RAB9ANPC1SMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2356109-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010042925-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | PRKCH, PRKCG, PRKCQ | RAB9A 2196/4885NPC1 1647/4885SMN1; SMN2 2857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.