Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226267 | 0.89 | KARS1 (0.53) | KARS1NPC1RAB9A | |
| SCHEMBL2226095 | 0.74 | KARS1 (0.46) | KARS1ALDH1A1SMN1; SMN2MAPK10L3MBTL1 | |
| SCHEMBL16531388 | 0.74 | KARS1 (0.46) | KARS1ALDH1A1SMN1; SMN2MAPK10L3MBTL1 | |
| SCHEMBL2225653 | 0.72 | KARS1 (0.53) | KARS1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13136173 | 0.71 | KARS1 (0.48) | KARS1ALDH1A1SMN1; SMN2MAPK10L3MBTL1 | |
| SCHEMBL13136171 | 0.71 | KARS1 (0.47) | KARS1ALDH1A1SMN1; SMN2MAPK10L3MBTL1 | |
| SCHEMBL2227897 | 0.70 | KARS1 (0.47) | KARS1ALDH1A1SMN1; SMN2MAPK10L3MBTL1 | |
| SCHEMBL2225285 | 0.69 | KARS1 (0.47) | KARS1ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL2225286 | 0.69 | KARS1 (0.47) | KARS1ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL13136238 | 0.67 | KARS1 (0.47) | KARS1ALDH1A1SMN1; SMN2MAPK10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523952-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | AB Science (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086085-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | AB SCIENCE (FR) | 2011-07-21 | — | — | WO | disclosed |