SCHEMBL2354448

SCHEMBL2354448

C1=C(Cc2ccccn2)c2ccccc2C1Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.57
L3MBTL1 Q9Y468 1/20 0.39
KDM4E B2RXH2 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
PKM P14618 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP2D6 P10635 1/20 0.35
POLB P06746 1/20 0.35
HRH3 Q9Y5N1 2/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
HRH4 Q9H3N8 1/20 0.34
LMNA P02545 1/20 0.34
ABCB1 P08183 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2353720 0.89 HTR6 (0.50) HTR6L3MBTL1KDM4ESMN1; SMN2NPC1
SCHEMBL27943263 0.86 HTR6 (0.60) HTR6L3MBTL1NPC1RAB9ACYP1A2
SCHEMBL28843652 0.83 HTR6 (0.68) HTR6MAOAMAOB
SCHEMBL28790807 0.82 HTR6 (0.52) HTR6L3MBTL1KDM4ECYP1A2CYP3A4
SCHEMBL5004055 0.81 HTR6 (0.38) HTR6L3MBTL1NPC1RAB9AMEN1
SCHEMBL5003994 0.79 MAPT (0.41) HTR6KDM4ESMN1; SMN2NPC1CYP1A2
SCHEMBL5003769 0.78 PIP4K2C (0.36) HTR6KDM4ECYP1A2CYP3A4ALDH1A1
SCHEMBL5004387 0.76 HTR6 (0.38) HTR6L3MBTL1NPC1RAB9AMEN1
SCHEMBL2463207 0.75 HRH3 (0.38) HTR6L3MBTL1MEN1ALDH1A1PKM
SCHEMBL5004311 0.75 HTR6 (0.42) HTR6L3MBTL1KDM4ESMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722832-B2 Ethylene terpolymers BASELL POLYOLEFINE GMBH (DE) 2014-05-13 US disclosed
US-8722832-B2 Ethylene terpolymers BASELL POLYOLEFINE GMBH (DE) 2014-05-13 US disclosed
US-8722832-B2 Ethylene terpolymers BASELL POLYOLEFINE GMBH (DE) 2014-05-13 US disclosed
US-8207269-B2 Process for obtaining polymers of ethylene and cycloolefins BASELL POLYOLEFINE GMBH (DE) 2012-06-26 US disclosed
US-8207269-B2 Process for obtaining polymers of ethylene and cycloolefins BASELL POLYOLEFINE GMBH (DE) 2012-06-26 US disclosed
EP-2245076-B1 ETHYLENE TERPOLYMERS BASELL POLYOLEFINE GMBH (DE) 2011-08-31 EP disclosed
EP-2245076-B1 ETHYLENE TERPOLYMERS BASELL POLYOLEFINE GMBH (DE) 2011-08-31 EP disclosed
US-20100298501-A1 ETHYLENE TERPOLYMERS BASELL POLYOLEFINE GMBH (DE) 2010-11-25 US disclosed
US-20100298501-A1 ETHYLENE TERPOLYMERS BASELL POLYOLEFINE GMBH (DE) 2010-11-25 US disclosed
US-20100267901-A1 PROCESS FOR OBTAINING POLYMERS OF ETHYLENE AND CYCLOOLEFINS BASELL POLYOLEFINE GMBH (DE) 2010-10-21 US disclosed
US-20100267901-A1 PROCESS FOR OBTAINING POLYMERS OF ETHYLENE AND CYCLOOLEFINS BASELL POLYOLEFINE GMBH (DE) 2010-10-21 US disclosed
WO-2009080174-A1 ETHYLENE TERPOLYMERS BASELL POLYOLEFINE GMBH (DE) 2009-07-02 WO disclosed