SCHEMBL23547465

SCHEMBL23547465

CC(C)(C)OC(=O)N1CCC(Nc2nc(S(C)(=O)=O)nn3c(Br)cnc23)CC1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 9/20 0.50
ALDH1A1 P00352 2/20 0.42
PIK3CA P42336 2/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
NSD2 O96028 1/20 0.42
USP30 Q70CQ3 1/20 0.41
ADORA1 P30542 1/20 0.41
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
PIK3CD O00329 1/20 0.40
KDM1A O60341 1/20 0.40
EHMT2 Q96KQ7 1/20 0.40
RCOR1 Q9UKL0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23547417 0.87 ALDH1A1 (0.45) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL23547451 0.85 ALDH1A1 (0.44) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL23547555 0.84 ALDH1A1 (0.49) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL23547466 0.83 ALDH1A1 (0.46) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL276378 0.79 GPR119 (0.52) GPR119ALDH1A1PIK3CANPC1MAPT
SCHEMBL23547405 0.74 ALDH1A1 (0.50) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL23547423 0.74 ALDH1A1 (0.46) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL23547419 0.73 ALDH1A1 (0.43) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL2235171 0.73 ALDH1A1 (0.49) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL23547553 0.73 ALDH1A1 (0.45) GPR119ALDH1A1NPC1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021121390-A1 HETEROCYCLIC COMPOUND, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND APPLICATION THEREOF 苏州信诺维医药科技股份有限公司 2021-06-24 WO disclosed