Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24491308 | 0.85 | KDM1A (0.42) | NAMPTJAK3 | |
| SCHEMBL23551340 | 0.81 | JAK2 (0.43) | JAK3CTSLCTSSCTSK | |
| SCHEMBL27368338 | 0.77 | POLB (0.41) | — | |
| SCHEMBL24125410 | 0.76 | NAMPT (0.40) | NAMPTJAK3 | |
| SCHEMBL27362636 | 0.74 | RAB9A (0.37) | — | |
| SCHEMBL24421312 | 0.73 | CTSL (0.33) | NAMPTCTSLCTSBCTSSCTSK | |
| SCHEMBL7398684 | 0.71 | NAMPT (0.42) | NAMPTJAK3CTSLCTSBCTSS | |
| SCHEMBL24891481 | 0.71 | NAMPT (0.36) | NAMPT | |
| SCHEMBL21788531 | 0.69 | SLC18A3 (0.50) | NAMPTJAK3 | |
| SCHEMBL4764984 | 0.69 | NAMPT (0.56) | NAMPTJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127561-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | C4 THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |