Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 14/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34433487 | 0.87 | PRMT5 (0.49) | ADRA1AHPGDHSP90AA1HSP90AB1 | |
| SCHEMBL34433490 | 0.87 | PRMT5 (0.49) | ADRA1AHPGDHSP90AA1HSP90AB1 | |
| SCHEMBL23553503 | 0.87 | PRMT5 (0.49) | ADRA1AHPGDHSP90AA1HSP90AB1 | |
| SCHEMBL23553502 | 0.87 | PRMT5 (0.49) | ADRA1AHPGDHSP90AA1HSP90AB1 | |
| SCHEMBL16846303 | 0.80 | ADRA1A (0.68) | ADRA1AHPGDL3MBTL3L3MBTL1 | |
| SCHEMBL16846280 | 0.75 | ADRA1A (1.00) | ADRA1AHPGD | |
| SCHEMBL22418711 | 0.75 | ADRA1A (0.61) | ADRA1AL3MBTL3L3MBTL1 | |
| SCHEMBL30823775 | 0.75 | ADRA1A (0.61) | ADRA1AL3MBTL3L3MBTL1 | |
| SCHEMBL16846245 | 0.75 | ADRA1A (1.00) | ADRA1A | |
| SCHEMBL16846289 | 0.74 | ADRA1A (1.00) | ADRA1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126728-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |