Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23553503 | 1.00 | PRMT5 (0.49) | PRMT5WDR77ADRA1AHPGDSLC18A3 | |
| SCHEMBL23553502 | 1.00 | PRMT5 (0.49) | PRMT5WDR77ADRA1AHPGDSLC18A3 | |
| SCHEMBL34433490 | 1.00 | PRMT5 (0.49) | PRMT5WDR77ADRA1AHPGDSLC18A3 | |
| SCHEMBL23553504 | 0.87 | ADRA1A (0.60) | ADRA1AHPGDHSP90AA1HSP90AB1 | |
| SCHEMBL30023676 | 0.77 | SCN9A (0.58) | PRMT5WDR77ADRA1A | |
| SCHEMBL30024823 | 0.77 | SCN9A (0.58) | PRMT5WDR77ADRA1A | |
| SCHEMBL23535202 | 0.77 | SCN9A (0.58) | PRMT5WDR77ADRA1A | |
| SCHEMBL23535448 | 0.77 | SCN9A (0.58) | PRMT5WDR77ADRA1A | |
| SCHEMBL30024775 | 0.77 | SLC18A3 (0.53) | PRMT5WDR77ADRA1AHPGDSLC18A3 | |
| SCHEMBL25387740 | 0.76 | SLC18A3 (0.52) | PRMT5WDR77ADRA1AHPGDSLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12595248-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12595248-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 108/4885ADRA1A 1439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.