Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | IDH2 | P48735 | 3/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23554146 | 0.87 | MEN1 (0.46) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL23554096 | 0.80 | VCP (0.64) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL23554055 | 0.80 | VCP (0.57) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL30041411 | 0.79 | KIF11 (0.59) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL23539563 | 0.79 | KIF11 (0.59) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL23691149 | 0.78 | IDH2 (0.47) | NPC1RAB9AMAPTMAPK1IDH2 | |
| SCHEMBL23539803 | 0.77 | SYK (0.47) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL23553843 | 0.74 | MEN1 (0.48) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL23540029 | 0.72 | MAPT (0.46) | MEN1KMT2ANPC1CASP3RAB9A | |
| SCHEMBL30041718 | 0.72 | MAPT (0.46) | MEN1KMT2ANPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127301-A1 | 4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |