Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.60 |
| ▸ | CFTR | P13569 | 2/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.56 |
| ▸ | VCP | P55072 | 3/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23554096 | 0.88 | VCP (0.64) | ALOX5CFTRVCPMAPTMAPK1 | |
| SCHEMBL23539499 | 0.86 | ALOX5 (0.60) | ALOX5CFTRNPY5RVCPAMY1A | |
| SCHEMBL1822809 | 0.85 | ALOX5 (0.76) | ALOX5CFTRNPY5RVCPAMY1A | |
| SCHEMBL23553823 | 0.80 | MEN1 (0.49) | ALOX5CFTRVCPAMY1APKM | |
| SCHEMBL1888054 | 0.79 | ALOX5 (0.78) | ALOX5CFTRNPY5RVCPAMY1A | |
| SCHEMBL31126438 | 0.77 | ALOX5 (0.64) | ALOX5CFTRNPY5RVCPMAPT | |
| SCHEMBL5026675 | 0.77 | ALOX5 (0.64) | ALOX5CFTRNPY5RVCPMAPT | |
| SCHEMBL207658 | 0.77 | MEN1 (0.75) | ALOX5NPY5RVCPPKMMAPT | |
| SCHEMBL31126428 | 0.76 | ALOX5 (0.78) | ALOX5NPY5RVCPAMY1AMAPT | |
| SCHEMBL23539595 | 0.76 | ALOX5 (0.73) | ALOX5CFTRNPY5RVCPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127301-A1 | 4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |