Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 17/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 17/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 15/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.64 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997450 | 0.86 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL23554349 | 0.84 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2657908 | 0.83 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2657907 | 0.83 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2658946 | 0.83 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2657548 | 0.82 | GABRG2 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL23554590 | 0.82 | GABRG2 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL23554672 | 0.81 | GABRA1 (0.48) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL23554502 | 0.81 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2658641 | 0.81 | GABRG2 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230136194-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2023-05-04 | — | — | US | disclosed |
| US-20230136194-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2023-05-04 | — | — | US | disclosed |
| WO-2021121294-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2021-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230136194-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | ABCG2, CYP4F8, CYP3A5 | GABRA1 858/4885GABRG2 1601/4885GABRB3 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.