Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 3/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261108 | 0.81 | — | — | |
| SCHEMBL19187973 | 0.81 | DRD2 (0.39) | DRD2PRMT1FFAR3 | |
| SCHEMBL3477725 | 0.78 | DRD2 (0.46) | DRD2PRMT1SMN1; SMN2OPRD1 | |
| SCHEMBL18505961 | 0.77 | DRD2 (0.30) | DRD2 | |
| SCHEMBL24127261 | 0.77 | CYP1A2 (0.32) | SCN1ASCN2ASCN3ACYP1A2TDP1 | |
| SCHEMBL14984980 | 0.77 | HSD11B1 (0.41) | DRD2PRMT1FFAR3TSHRSMN1; SMN2 | |
| SCHEMBL25157364 | 0.77 | FFAR3 (0.38) | DRD2PRMT1FFAR3TSHRSMN1; SMN2 | |
| SCHEMBL2055524 | 0.75 | HSD11B1 (0.44) | DRD2FFAR3SMN1; SMN2 | |
| SCHEMBL16892268 | 0.75 | CYP1A2 (0.42) | SCN1ASCN2ASCN3ACYP1A2TDP1 | |
| SCHEMBL2055540 | 0.75 | FFAR3 (0.62) | DRD2SCN1ASCN2ASCN3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127328-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |