Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.54 |
| ▸ | TP53 | P04637 | 11/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.54 |
| ▸ | RAB9A | P51151 | 10/20 | 0.54 |
| ▸ | HPGD | P15428 | 10/20 | 0.54 |
| ▸ | NPC1 | O15118 | 9/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.53 |
| ▸ | RELA | Q04206 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 3/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25857103 | 0.86 | MAPT (0.46) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL25857180 | 0.81 | KDM6B (0.40) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL25857105 | 0.79 | APP (0.50) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL25857096 | 0.79 | NPC1 (0.42) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL25857098 | 0.79 | NPC1 (0.43) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL2491813 | 0.78 | RAB9A (0.69) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL10219881 | 0.77 | BCHE (0.52) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL2242651 | 0.77 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL23558391 | 0.76 | TLR7 (0.37) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A | |
| SCHEMBL25857106 | 0.76 | RAB9A (0.41) | ALDH1A1SMN1; SMN2TP53KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | ALDH1A1 2583/4885SMN1; SMN2 1320/4885TP53 4030/4885 |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | ALDH1A1 2583/4885SMN1; SMN2 1320/4885TP53 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.