SCHEMBL2355876

SCHEMBL2355876

O=C(O)N1CCC(COc2ccc3c(F)cccc3c2)C1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.42
FFAR1 O14842 2/20 0.41
RBP4 P02753 2/20 0.40
PPARD Q03181 2/20 0.39
HCRTR1 O43613 1/20 0.39
HCRTR2 O43614 1/20 0.39
PARP10 Q53GL7 2/20 0.39
PARP15 Q460N3 1/20 0.39
PPARA Q07869 1/20 0.39
TTR P02766 1/20 0.39
GRIN2D O15399 1/20 0.38
GRIN3B O60391 1/20 0.38
GRIN1 Q05586 1/20 0.38
GRIN2A Q12879 1/20 0.38
GRIN2B Q13224 1/20 0.38
GRIN2C Q14957 1/20 0.38
GRIN3A Q8TCU5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2358210 0.87 F2 (0.43) FFAR1RBP4TTRGRIN2DGRIN3B
SCHEMBL2227841 0.85 SLC6A2 (0.52) RBP4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL2227838 0.85 SLC6A2 (0.52) RBP4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL2285047 0.85 SLC6A2 (0.52) RBP4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL2228670 0.80 MMP2 (0.45) HCRTR1HCRTR2GRIN2B
SCHEMBL20744482 0.78 CHRNB4 (0.52) FFAR4FFAR1RBP4GRIN2DGRIN3B
SCHEMBL20744410 0.78 CHRNB4 (0.52) FFAR4FFAR1RBP4GRIN2DGRIN3B
SCHEMBL20744463 0.78 CHRNB4 (0.52) FFAR4FFAR1RBP4GRIN2DGRIN3B
SCHEMBL31330838 0.76 CYP4F2 (0.42) PARP10PARP15
SCHEMBL2227810 0.76 MEN1 (0.51) RBP4HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011089550-A1 ALKYL-HETEROCYCLE CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI AVENTIS (FR) 2011-07-28 WO claimed