Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210171 | 0.86 | NR1H2 (0.46) | NR1H2NAMPTUSP2SMN1; SMN2GLS | |
| SCHEMBL2300645 | 0.85 | NR1H2 (0.43) | NR1H2NAMPTUSP2SMN1; SMN2GLS | |
| SCHEMBL29239203 | 0.85 | NR1H2 (0.38) | NR1H2 | |
| SCHEMBL2299142 | 0.85 | NR1H2 (0.76) | NR1H2NAMPTUSP2SMN1; SMN2RECQL | |
| SCHEMBL14242309 | 0.82 | NR1H2 (0.57) | NR1H2NAMPTUSP2SMN1; SMN2GLS | |
| SCHEMBL1018269 | 0.82 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2GLS | |
| SCHEMBL16096256 | 0.82 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2GLS | |
| SCHEMBL2929277 | 0.82 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2GLS | |
| SCHEMBL1914060 | 0.81 | NR1H2 (0.43) | NR1H2MEN1ALDH1A1KMT2A | |
| SCHEMBL584186 | 0.81 | NR1H2 (0.43) | NR1H2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103127-A1 | TREATMENT OF METABOLIC SYNDROME WITH PIPERIDINE AMIDES | AMPLA PHARMACEUTICALS INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011103127-A1 | TREATMENT OF METABOLIC SYNDROME WITH PIPERIDINE AMIDES | AMPLA PHARMACEUTICALS INC. (US) | 2011-08-25 | — | — | WO | disclosed |