Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23696532 | 0.89 | KDM4E (0.42) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL26406493 | 0.89 | KDM4E (0.36) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24672987 | 0.89 | KDM4E (0.42) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24673349 | 0.89 | TP53 (0.34) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL25477793 | 0.87 | ALDH1A1 (0.40) | TP53SMN1; SMN2KDM4EALDH1A1USP2 | |
| SCHEMBL22837636 | 0.86 | SLC2A1 (0.34) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21107593 | 0.86 | SLC2A1 (0.34) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24029376 | 0.86 | CARM1 (0.36) | TP53SMN1; SMN2KDM4EALDH1A1SCN1A | |
| SCHEMBL25972118 | 0.85 | HTT (0.34) | HTTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL23696051 | 0.84 | SLC2A1 (0.35) | TP53SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127278-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |