Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23127091 | 0.80 | GPR119 (0.39) | EPHX1TSHRHPGDLMNAHSD17B10 | |
| SCHEMBL4528244 | 0.80 | NPSR1 (0.48) | NPSR1EPHX1HTR2CHPGDLMNA | |
| SCHEMBL2730627 | 0.79 | SPR (0.49) | NPSR1SPRTSHRHPGDLMNA | |
| SCHEMBL5383679 | 0.78 | MEN1 (0.54) | EPHX1SIGMAR1MEN1KMT2A | |
| SCHEMBL8397010 | 0.78 | EPHX1 (0.45) | EPHX1TSHRSIGMAR1 | |
| SCHEMBL22893225 | 0.78 | BCHE (0.37) | EPHX1SIGMAR1 | |
| SCHEMBL18315998 | 0.76 | EPHX1 (0.42) | EPHX1HPGDALDH1A1SIGMAR1 | |
| SCHEMBL11929599 | 0.75 | EPHX2 (0.45) | EPHX1HPGDPOLBKMT2A | |
| SCHEMBL8326097 | 0.74 | TSHR (0.54) | NPSR1SPREPHX1TSHRLMNA | |
| SCHEMBL23564649 | 0.74 | EPHX1 (0.41) | EPHX1ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127499-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CALICO LIFE SCIENCES LLC (US) | 2021-06-24 | — | — | WO | disclosed |