Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28892106 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL12537716 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL28632731 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL5872667 | 0.74 | ALDH1A1 (0.35) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL5872671 | 0.74 | ALDH1A1 (0.35) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL30138720 | 0.73 | KDM4E (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL637370 | 0.73 | KDM4E (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL637369 | 0.73 | KDM4E (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL637368 | 0.73 | KDM4E (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL12613304 | 0.71 | CES1 (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898832-B1 | POLYOLEFIN FIBRES | BASELL POLIOLEFINE ITALIA SRL (IT) | 2023-11-08 | — | — | EP | disclosed |
| US-20220106717-A1 | POLYOLEFIN FIBRES | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2022-04-07 | — | — | US | disclosed |
| CN-113166505-A | Polyolefin fibers | 巴塞尔聚烯烃意大利有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-2225324-B1 | POLYOLEFIN FIBRES | BASELL POLIOLEFINE ITALIA SRL (IT) | 2016-12-14 | — | — | EP | disclosed |
| US-9006341-B2 | Polyolefin fibres | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2015-04-14 | — | — | US | disclosed |
| US-20110238027-A1 | Polyolefin Fibres | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2011-09-29 | — | — | US | disclosed |
| EP-2358809-A1 | POLYOLEFIN FIBRES | Basell Poliolefine Italia S.R.L. (IT) | 2011-08-24 | — | — | EP | disclosed |
| CN-101910285-A | Polyolefin fibres | BASELL POLIOLEFINE SRL | 2010-12-08 | — | — | CN | disclosed |
| US-20100267305-A1 | POLYOLEFIN FIBRES | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2010-10-21 | — | — | US | disclosed |
| EP-2225324-A1 | POLYOLEFIN FIBRES | Basell Poliolefine Italia S.R.L. (IT) | 2010-09-08 | — | — | EP | disclosed |
| WO-2010069775-A1 | Polyolefin Fibres | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2010-06-24 | — | — | WO | disclosed |
| WO-2009080435-A1 | POLYOLEFIN FIBRES | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2009-07-02 | — | — | WO | disclosed |
| CN-100339400-C | High stereospecific polybutylene polymer and process for preparation thereof | YLEM TECHNOLOGY HOLDINGS INC (KR) | 2007-09-26 | — | — | CN | disclosed |
| CN-1590417-A | High stereospecific polybutylene polymer and process for preparation thereof | YLEM TECHNOLOGY HOLDINGS INC (KR) | 2005-03-09 | — | — | CN | disclosed |
| EP-1153047-A1 | METALLOCENE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN CATALYTIC SYSTEMS FOR THE POLYMERIZATION OF OLEFINS | Basell Technology Company B.V. (NL) | 2001-11-14 | — | — | EP | disclosed |
| WO-2001044318-A1 | METALLOCENE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN CATALYTIC SYSTEMS FOR THE POLYMERIZATION OF OLEFINS | BASELL TECHNOLOGY COMPANY B.V. (NL) | 2001-06-21 | — | — | WO | disclosed |
| WO-1997005178-A1 | IMPROVED METHOD FOR PREPARING METALLOCENE CATALYST SYSTEMS | EXXON CHEMICAL PATENTS INC. (US) | 1997-02-13 | — | — | WO | disclosed |