SCHEMBL235662

SCHEMBL235662

C=C(C)C(=O)OCC(O)CO[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.47
ALDH1A1 P00352 2/20 0.36
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13863105 0.88 TSHR (0.47) TSHRALDH1A1THRB
SCHEMBL2189982 0.81 TSHR (0.41) TSHRALDH1A1THRB
SCHEMBL94906 0.81 TSHR (0.68) TSHRALDH1A1THRB
SCHEMBL29343526 0.79 TSHR (0.49) TSHRALDH1A1THRB
SCHEMBL17805317 0.79 TSHR (0.49) TSHRALDH1A1THRB
SCHEMBL29343527 0.79 TSHR (0.49) TSHRALDH1A1THRB
SCHEMBL13863117 0.79 TSHR (0.49) TSHRALDH1A1THRB
SCHEMBL3627742 0.79 TSHR (0.49) TSHRALDH1A1THRB
SCHEMBL29343519 0.79 TSHR (0.53) TSHRALDH1A1THRB
SCHEMBL19998240 0.79 TSHR (0.65) TSHRALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8349912-B2 Crosslink agents and dual radical cure polymer BAUSCH & LOMB INCORPORATED (US) 2013-01-08 US claimed
US-20120004380-A1 Crosslink Agents and Dual Radical Cure Polymer BAUSCH HEALTH AMERICAS, INC. 2012-01-05 US claimed
US-8053489-B2 Crosslink agents and dual radical cure polymer BAUSCH & LOMB INCORPORATED (US) 2011-11-08 US claimed
EP-3424965-B1 CROSSLINK AGENTS AND ITS USE BAUSCH & LOMB (US) 2020-05-13 EP disclosed
EP-3424965-A1 CROSSLINK AGENTS AND DUAL RADICAL CURE POLYMER Bausch & Lomb Incorporated (US) 2019-01-09 EP disclosed
EP-2167555-B1 CROSSLINK AGENTS AND DUAL RADICAL CURE POLYMER BAUSCH & LOMB (US) 2018-10-10 EP disclosed
US-8349912-B2 Crosslink agents and dual radical cure polymer BAUSCH & LOMB INCORPORATED (US) 2013-01-08 US disclosed
US-8252850-B2 Crosslink agents BAUSCH & LOMB INCORPORATED (US) 2012-08-28 US disclosed
US-8119753-B2 Silicone hydrogels with amino surface groups BAUSCH & LOMB INCORPORATED (US) 2012-02-21 US disclosed
US-20120004380-A1 Crosslink Agents and Dual Radical Cure Polymer BAUSCH HEALTH AMERICAS, INC. 2012-01-05 US disclosed
US-8053489-B2 Crosslink agents and dual radical cure polymer BAUSCH & LOMB INCORPORATED (US) 2011-11-08 US disclosed
EP-2170966-A1 CROSSLINK AGENTS AND DUAL RADICAL CURE POLYMER Bausch & Lomb Incorporated (US) 2010-04-07 EP disclosed
EP-2167555-A1 CROSSLINK AGENTS AND DUAL RADICAL CURE POLYMER Bausch & Lomb Incorporated (US) 2010-03-31 EP disclosed
WO-2009111296-A1 POLYSILOXANES AND POLYSILOXANE PREPOLYMERS WITH VINYL OR EPOXY FUNCTIONALITY BAUSCH & LOMB INCORPORATED (US) 2009-09-11 WO disclosed
US-20090227804-A1 POLYSILOXANES AND POLYSILOXANE PREPOLYMERS WITH VINYL OR EPOXY FUNCTIONALITY PRECISION DERMATOLOGY, INC. 2009-09-10 US disclosed
US-20090103045-A1 SILICONE HYDROGELS WITH AMINO SURFACE GROUPS SALIX PHARMACEUTICALS, INC. 2009-04-23 US disclosed
WO-2009014923-A1 CROSSLINK AGENTS AND DUAL RADICAL CURE POLYMER BAUSCH & LOMB INCORPORATED (US) 2009-01-29 WO disclosed
US-20090023876-A1 Crosslink Agents and Dual Radical Cure Polymer MEDICIS PHARMACEUTICAL CORPORATION 2009-01-22 US disclosed
US-20090018233-A1 Crosslink Agents and Dual Radical Cure Polymer SOLTA MEDICAL, INC. 2009-01-15 US disclosed
WO-2009009527-A1 CROSSLINK AGENTS AND DUAL RADICAL CURE POLYMER BAUSCH & LOMB INCORPORATED (US) 2009-01-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018233-A1 Crosslink Agents and Dual Radical Cure Polymer UACA, CRYAA, RAD51 TSHR 2555/4885ALDH1A1 1327/4885THRB 4577/4885
US-20090227804-A1 POLYSILOXANES AND POLYSILOXANE PREPOLYMERS WITH VINYL OR EPOXY FUNCTIONALITY MUS81, UTS2R, C1R TSHR 2214/4885ALDH1A1 2339/4885THRB 3182/4885
US-20120004380-A1 Crosslink Agents and Dual Radical Cure Polymer UACA, CRYAA, PCNA TSHR 2788/4885ALDH1A1 883/4885THRB 4718/4885
US-20090023876-A1 Crosslink Agents and Dual Radical Cure Polymer UACA, CRYAA, PCNA TSHR 2788/4885ALDH1A1 883/4885THRB 4718/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.