Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25469081 | 0.85 | PRMT6 (0.40) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL23567930 | 0.81 | CARM1 (0.42) | CHRM4PIK3CDCYP2D6HRH3CARM1 | |
| SCHEMBL25691521 | 0.80 | PIK3CD (0.43) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL22848538 | 0.79 | CHRM4 (0.38) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL23945990 | 0.78 | CHRM4 (0.37) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL25883845 | 0.77 | CHRM4 (0.36) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL24673663 | 0.75 | CHRM4 (0.36) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL23560007 | 0.75 | SIGMAR1 (0.44) | CHRM4PIK3CDHRH3CARM1PRMT6 | |
| SCHEMBL23695997 | 0.74 | PIK3CD (0.44) | CHRM4PIK3CDCYP2D6HRH3KDM4E | |
| SCHEMBL13512410 | 0.74 | PIK3CD (0.39) | CHRM4PIK3CDCYP2D6HRH3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |