Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 7/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23568906 | 1.00 | PDK1 (0.35) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL22856298 | 0.89 | PDK1 (0.36) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL21107633 | 0.89 | PDK1 (0.36) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL21106060 | 0.89 | PDK1 (0.36) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL22802807 | 0.88 | ALDH1A1 (0.41) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL24508708 | 0.88 | ALDH1A1 (0.41) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL22802803 | 0.88 | ALDH1A1 (0.41) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL24379939 | 0.86 | ALDH1A1 (0.40) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL25883265 | 0.86 | ALDH1A1 (0.40) | PDK1DRD4HRH3ALDH1A1 | |
| SCHEMBL23560447 | 0.85 | PDK1 (0.49) | PDK1DRD4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192586-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |