Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359768 | 0.92 | BRAF (0.35) | BRAFHCRTR2MAPK3MAPK1PTGS2 | |
| SCHEMBL2358612 | 0.91 | HCRTR2 (0.35) | BRAFHCRTR2MAPK3MAPK1PTGS1 | |
| SCHEMBL2359353 | 0.90 | BRAF (0.31) | BRAFHCRTR2MAPK3MAPK1MAPK8 | |
| SCHEMBL2359853 | 0.90 | BRAF (0.33) | BRAFMAPK3MAPK1 | |
| SCHEMBL14108512 | 0.89 | PTGS2 (0.34) | BRAFHCRTR2MAPK3MAPK1PTGS2 | |
| SCHEMBL2315626 | 0.89 | BRAF (0.33) | BRAFHCRTR2MAPK3MAPK1PTGS2 | |
| SCHEMBL2359767 | 0.87 | BRAF (0.33) | BRAFMAPK3MAPK1 | |
| SCHEMBL2318038 | 0.87 | HCRTR2 (0.36) | BRAFHCRTR2MAPK3MAPK1PTGS2 | |
| SCHEMBL2319762 | 0.85 | ACLY (0.35) | BRAFHCRTR2MAPK3MAPK1PTGS2 | |
| SCHEMBL2359191 | 0.84 | BRAF (0.33) | BRAFMAPK3MAPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | claimed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |