Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.31 |
| ▸ | TXK | P42681 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20314877 | 1.00 | JAK3 (0.39) | JAK3SMN1; SMN2SLC6A9MAPTTSHR | |
| SCHEMBL22185432 | 1.00 | JAK3 (0.39) | JAK3SMN1; SMN2SLC6A9MAPTTSHR | |
| SCHEMBL23366022 | 0.90 | JAK3 (0.38) | JAK3SMN1; SMN2TSHRHRH3TXK | |
| SCHEMBL23735937 | 0.84 | JAK3 (0.39) | JAK3SMN1; SMN2TXKBTK | |
| SCHEMBL24870546 | 0.81 | JAK3 (0.36) | JAK3SMN1; SMN2SLC6A9HRH3 | |
| SCHEMBL27281065 | 0.81 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL27280634 | 0.81 | JAK3 (0.33) | JAK3HRH3 | |
| SCHEMBL23848396 | 0.81 | JAK3 (0.34) | JAK3HRH3 | |
| SCHEMBL20314977 | 0.81 | CACNA1A (0.36) | MAPT | |
| SCHEMBL23569909 | 0.80 | JAK3 (0.42) | JAK3TXKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787811-B2 | KRAS mutant protein inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-10-17 | — | — | US | disclosed |
| US-11787811-B2 | KRAS mutant protein inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-10-17 | — | — | US | disclosed |
| US-11384087-B1 | — | — | 2022-07-12 | — | — | US | disclosed |
| WO-2022111513-A1 | AROMATIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州多域生物技术有限公司 | 2022-06-02 | — | — | WO | disclosed |
| US-11161847-B2 | KRAS mutant protein inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-11-02 | — | — | US | disclosed |
| US-20210300920-A1 | KRAS Mutant Protein Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2021-09-30 | — | — | US | disclosed |
| WO-2021121367-A1 | KRAS MUTANT PROTEIN INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300920-A1 | KRAS Mutant Protein Inhibitors | KRAS, NRAS, APC | JAK3 2071/4885SMN1; SMN2 3908/4885SLC6A9 4393/4885 |
| US-11161847-B2 | KRAS mutant protein inhibitors | KRAS, NRAS, APC | JAK3 2071/4885SMN1; SMN2 3908/4885SLC6A9 4393/4885 |
| US-11384087-B1 | — | KRAS, NRAS, APC | JAK3 2661/4885SMN1; SMN2 3280/4885SLC6A9 4340/4885 |
| US-11787811-B2 | KRAS mutant protein inhibitors | KRAS, NRAS, APC | JAK3 2361/4885SMN1; SMN2 3852/4885SLC6A9 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.