Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 6/20 | 0.41 |
| ▸ | BRD7 | Q9NPI1 | 6/20 | 0.41 |
| ▸ | BRD4 | O60885 | 6/20 | 0.41 |
| ▸ | TAF1 | P21675 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | ATAD2B | Q9ULI0 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 3/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23575703 | 0.89 | BRD9 (0.47) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23575605 | 0.86 | BRD9 (0.48) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23575665 | 0.84 | BRD4 (0.42) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL25846074 | 0.84 | BRD4 (0.42) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23575624 | 0.84 | PKM (0.46) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23575291 | 0.84 | BRD9 (0.45) | BRD9BRD7BRD4TAF1TGFBR1 | |
| SCHEMBL23783175 | 0.82 | PKM (0.44) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23798558 | 0.81 | BRD4 (0.43) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23783382 | 0.80 | BRD4 (0.43) | PKMPKLRBRD9BRD7BRD4 | |
| SCHEMBL23798555 | 0.80 | BRD4 (0.42) | PKMPKLRBRD9BRD7BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846800-A1 | COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1 | C4 Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |
| US-20210198256-A1 | COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1 | C4 THERAPEUTICS, INC. (US) | 2021-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198256-A1 | COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1 | RBBP9, MTHFD1, BRWD1 | PKM 4022/4885PKLR 3801/4885BRD9 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.