Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.33 |
| ▸ | HIPK3 | Q9H422 | 2/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RPS27 | P42677 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359458 | 0.84 | TYK2 (0.49) | TYK2PDE4DCSNK2A2CSNK2A1HIPK2 | |
| SCHEMBL3309971 | 0.84 | CSNK2A2 (0.42) | TYK2PDE4DCSNK2A2CSNK2A1HIPK2 | |
| SCHEMBL2309711 | 0.81 | CSNK2A2 (0.40) | CSNK2A2CSNK2A1HIPK2KCNH2DYRK3 | |
| SCHEMBL12012939 | 0.80 | EGFR (0.41) | TYK2PDE4DCSNK2A2CSNK2A1HIPK2 | |
| SCHEMBL15084633 | 0.76 | RPS27 (0.44) | TYK2PDE4DCSNK2A2CSNK2A1MAPT | |
| SCHEMBL2359440 | 0.75 | TYK2 (0.48) | TYK2CSNK2A2CSNK2A1HIPK2KCNH2 | |
| SCHEMBL3313770 | 0.75 | CSNK2A2 (0.36) | PDE4DCSNK2A2CSNK2A1PDE4APDE4B | |
| SCHEMBL12013383 | 0.75 | CSNK2A1 (0.39) | CSNK2A2CSNK2A1HIPK2KCNH2DYRK3 | |
| SCHEMBL2357817 | 0.74 | TYK2 (0.38) | TYK2PDE4DHIPK2CDK2GSK3B | |
| SCHEMBL13641723 | 0.74 | PIK3CA (0.37) | TYK2CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |
| US-20140179674-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-06-26 | — | — | US | disclosed |
| EP-2350081-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179674-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | MAP3K5, MAP3K15, MAP4K2 | TYK2 393/4885PDE4D 1445/4885CSNK2A2 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.