RPS27

Small ribosomal subunit protein eS27 · P42677 · RPS27 on Sugi Atlas →

5,040 patent compounds predicted against RPS27, 2,771 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL5805258 SCHEMBL5805258 0.50 6/20
SCHEMBL1146119 SCHEMBL1146119 0.49 6/20
SCHEMBL5804061 SCHEMBL5804061 0.81 5/20
SCHEMBL1145566 SCHEMBL1145566 0.74 5/20
SCHEMBL1144859 SCHEMBL1144859 0.68 5/20
SCHEMBL1145009 SCHEMBL1145009 0.59 5/20
SCHEMBL1145693 SCHEMBL1145693 0.56 5/20
SCHEMBL1145307 SCHEMBL1145307 0.69 4/20
SCHEMBL1146017 SCHEMBL1146017 0.66 4/20
SCHEMBL1145277 SCHEMBL1145277 0.64 4/20
SCHEMBL1145329 SCHEMBL1145329 0.63 4/20
SCHEMBL1316783 SCHEMBL1316783 0.57 4/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL1315428) 0.56 4/20
SCHEMBL5746478 SCHEMBL5746478 0.53 4/20
SCHEMBL2506250 SCHEMBL2506250 0.47 4/20
SCHEMBL1145762 SCHEMBL1145762 0.46 4/20
SCHEMBL5500526 SCHEMBL5500526 0.41 4/20
SCHEMBL5500532 SCHEMBL5500532 0.41 4/20
SCHEMBL5503310 SCHEMBL5503310 0.41 4/20
SCHEMBL1145640 SCHEMBL1145640 1.00 3/20

Clinical trials — most relevant to RPS27 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Proteome-based Immunotherapy of Lung Cancer Brain Metastases PHASE2/PHASE3UNKNOWN
Proteome-based Personalized Immunotherapy of Glioblastoma PHASE2/PHASE3UNKNOWN
Proteome-based Immunotherapy of Brain Metastases From Breast Cancer PHASE2/PHASE3UNKNOWN
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients PHASE2COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer PHASE1/PHASE2COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma PHASE2COMPLETED
Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma PHASE1/PHASE2COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients PHASE1/PHASE2COMPLETED
ISIS 183750 With Irinotecan for Advanced Solid Tumors or Colorectal Cancer PHASE1/PHASE2COMPLETED
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer PHASE2UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer PHASE1WITHDRAWN
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia PHASE1RECRUITING
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Testing of Micellar Casein, Blended Micellar Casein and Native Whey nanCOMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML) nanCOMPLETED
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS) nanRECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
RibOSE - Glucose and Resistance Exercise Training nanCOMPLETED
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma nanCOMPLETED
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
The Effects of Whey vs. Collagen on MPS nanCOMPLETED
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care nanCOMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress nanWITHDRAWN
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants. nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RPS27 binder may also engage these)

ProteinNameSimilarity
Q71TY3 1.000 Q71TY3 →
Q5RBK1 1.000 Q5RBK1 →
Q2KHT7 1.000 Q2KHT7 →
Q6ZWU9 1.000 Q6ZWU9 →
G1TZ76 1.000 G1TZ76 →
P47904 1.000 P47904 →
Q6ZWY3 1.000 Q6ZWY3 →
Q3T0B7 0.999 Q3T0B7 →
P24051 0.997 P24051 →
RPS27L Ribosomal protein eS27-like 0.997 landscape →
Q96564 0.996 Q96564 →
O74330 0.996 O74330 →
O64650 0.996 O64650 →
A0A1D8PTI7 0.996 A0A1D8PTI7 →
P35997 0.994 P35997 →
Q9M2F1 0.993 Q9M2F1 →
Q8L953 0.993 Q8L953 →
Q7RVN2 0.993 Q7RVN2 →
Q8T1V4 0.992 Q8T1V4 →
P38711 0.991 P38711 →
Q3E7A8 0.988 Q3E7A8 →
Q6GMD3 0.987 Q6GMD3 →
P55833 0.986 P55833 →
B3EMY1 0.986 B3EMY1 →
C6BYQ6 0.985 C6BYQ6 →
P05075 0.985 P05075 →
Q28GG3 0.985 Q28GG3 →
Q6AX78 0.985 Q6AX78 →
P47903 0.984 P47903 →
Q9CQA8 0.984 Q9CQA8 →