Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 6/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 3/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.45 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717773 | 0.92 | CSF1R (0.55) | BRAFABL1SRCBCREPHB2 | |
| SCHEMBL2358401 | 0.90 | BRAF (0.46) | BRAFABL1SRCBCREPHB2 | |
| SCHEMBL14110085 | 0.90 | ABL1 (0.56) | BRAFABL1SRCBCREPHB2 | |
| SCHEMBL2359009 | 0.88 | EPHB2 (0.53) | BRAFABL1BCREPHB2RAF1 | |
| SCHEMBL12433475 | 0.88 | ABL1 (0.63) | BRAFABL1SRCBCREPHB2 | |
| SCHEMBL12432449 | 0.87 | CSF1R (0.58) | BRAFABL1SRCBCREPHB2 | |
| SCHEMBL2357420 | 0.86 | ABL1 (0.51) | BRAFABL1BCREPHB2RAF1 | |
| SCHEMBL12433869 | 0.86 | CSF1R (0.57) | BRAFABL1SRCBCREPHB2 | |
| SCHEMBL14716921 | 0.84 | CSF1R (0.63) | BRAFABL1SRCRAF1CSF1R | |
| SCHEMBL2359059 | 0.84 | EPHB2 (0.50) | BRAFABL1BCREPHB2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | claimed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | claimed |
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |