Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB2 | P29323 | 1/20 | 0.50 |
| ▸ | NR2E1 | Q9Y466 | 8/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | LDLR | P01130 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357420 | 0.91 | ABL1 (0.51) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL2359009 | 0.89 | EPHB2 (0.53) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL2357417 | 0.86 | ABL1 (0.47) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL2359007 | 0.86 | CSF1R (0.47) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL14717948 | 0.84 | CSF1R (0.59) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL2358403 | 0.84 | BRAF (0.52) | EPHB2RAF1HCKNR2C2BTK | |
| SCHEMBL14717868 | 0.83 | CSF1R (0.59) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL12433883 | 0.83 | CSF1R (0.59) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL12433483 | 0.81 | CSF1R (0.62) | EPHB2NR2E1RAF1HCKNR2C2 | |
| SCHEMBL14110085 | 0.81 | ABL1 (0.56) | EPHB2NR2E1RAF1HCKNR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | claimed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | claimed |