Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584460 | 0.85 | PRMT5 (0.42) | PRMT5WDR77JAK2JAK1TYK2 | |
| SCHEMBL23584461 | 0.84 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL23584681 | 0.82 | HRH3 (0.41) | PRMT5WDR77 | |
| SCHEMBL23584706 | 0.81 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584672 | 0.81 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL19344479 | 0.80 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584630 | 0.79 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL23584561 | 0.79 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL23584449 | 0.79 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL18572827 | 0.78 | ALDH1A1 (0.42) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |