Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 12/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
| ▸ | AHCY | P23526 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584547 | 0.85 | PRMT5 (0.34) | PRMT5WDR77JAK2JAK1TYK2 | |
| SCHEMBL23584710 | 0.85 | PRMT5 (0.44) | PRMT5WDR77CHRNA7HTR3AADK | |
| SCHEMBL23584865 | 0.81 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL22524104 | 0.80 | PRMT5 (0.48) | PRMT5WDR77ADKYTHDC1 | |
| SCHEMBL23584625 | 0.74 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL23892515 | 0.71 | PRMT5 (0.44) | PRMT5WDR77ADKPIP4K2AYTHDC1 | |
| SCHEMBL19344219 | 0.70 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL19344097 | 0.70 | PRMT5 (0.47) | PRMT5WDR77ADK | |
| SCHEMBL19343921 | 0.70 | ADK (0.43) | PRMT5WDR77ADK | |
| SCHEMBL19344475 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |