⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584487 | 0.87 | — | — | |
| SCHEMBL23584590 | 0.87 | DOT1L (0.32) | — | |
| SCHEMBL23584801 | 0.87 | POLRMT (0.32) | — | |
| SCHEMBL23584730 | 0.83 | EGLN2 (0.30) | — | |
| SCHEMBL19344169 | 0.82 | POLRMT (0.35) | — | |
| SCHEMBL19344160 | 0.82 | POLRMT (0.35) | — | |
| SCHEMBL23584490 | 0.82 | — | — | |
| SCHEMBL19344174 | 0.82 | POLRMT (0.32) | — | |
| SCHEMBL23584486 | 0.80 | DOT1L (0.33) | — | |
| SCHEMBL19344281 | 0.80 | POLRMT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |