Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584843 | 0.92 | POLRMT (0.32) | POLRMT | |
| SCHEMBL23584534 | 0.89 | PRMT5 (0.34) | POLRMT | |
| SCHEMBL23584693 | 0.88 | DOT1L (0.35) | POLRMT | |
| SCHEMBL23584569 | 0.87 | — | — | |
| SCHEMBL19344169 | 0.86 | POLRMT (0.35) | POLRMT | |
| SCHEMBL19344160 | 0.86 | POLRMT (0.35) | POLRMT | |
| SCHEMBL23584648 | 0.84 | STING1 (0.33) | POLRMT | |
| SCHEMBL23584535 | 0.83 | POLRMT (0.31) | POLRMT | |
| SCHEMBL19344281 | 0.80 | POLRMT (0.31) | POLRMT | |
| SCHEMBL19344282 | 0.78 | POLRMT (0.30) | POLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |