Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434978 | 0.91 | PRMT5 (0.38) | PRMT5 | |
| SCHEMBL23584466 | 0.90 | PRMT5 (0.36) | PRMT5 | |
| SCHEMBL22435029 | 0.89 | PRMT5 (0.36) | PRMT5 | |
| SCHEMBL23584605 | 0.88 | PRMT5 (0.30) | PRMT5 | |
| SCHEMBL23584538 | 0.87 | PRMT5 (0.35) | PRMT5 | |
| SCHEMBL22435009 | 0.87 | PRMT5 (0.49) | PRMT5 | |
| SCHEMBL23584799 | 0.87 | PRMT5 (0.38) | PRMT5 | |
| SCHEMBL19344174 | 0.84 | POLRMT (0.32) | PRMT5 | |
| SCHEMBL22434806 | 0.83 | CNR2 (0.37) | PRMT5 | |
| SCHEMBL23584795 | 0.83 | CNR2 (0.37) | PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |