Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434806 | 1.00 | CNR2 (0.37) | CNR2PRMT5BACE1RIPK1MAP4K4 | |
| SCHEMBL19344499 | 0.91 | GPR119 (0.37) | BACE1RIPK1MAP4K4GPR119OPRD1 | |
| SCHEMBL23584737 | 0.90 | CNR2 (0.38) | CNR2BACE1CNR1GPR119OPRD1 | |
| SCHEMBL23584806 | 0.89 | CNR2 (0.37) | CNR2PRMT5BACE1RIPK1MAP4K4 | |
| SCHEMBL19344522 | 0.87 | CNR2 (0.35) | CNR2CNR1GPR119JAK2JAK1 | |
| SCHEMBL19344283 | 0.86 | PRMT5 (0.43) | CNR2PRMT5RIPK1MAP4K4OPRD1 | |
| SCHEMBL22434978 | 0.85 | PRMT5 (0.38) | PRMT5 | |
| SCHEMBL23584488 | 0.84 | RIPK1 (0.34) | CNR2RIPK1MAP4K4CNR1GPR119 | |
| SCHEMBL19344277 | 0.84 | PRMT5 (0.35) | CNR2PRMT5BACE1RIPK1MAP4K4 | |
| SCHEMBL23584601 | 0.83 | PRMT5 (0.37) | PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |