Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.32 |
| ▸ | NAMPT | P43490 | 6/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434806 | 0.90 | CNR2 (0.37) | CNR2CNR1GPR119NAMPTBACE1 | |
| SCHEMBL23584795 | 0.90 | CNR2 (0.37) | CNR2CNR1GPR119NAMPTBACE1 | |
| SCHEMBL19344522 | 0.86 | CNR2 (0.35) | CNR2CNR1GPR119NAMPT | |
| SCHEMBL23584685 | 0.85 | PRMT5 (0.31) | — | |
| SCHEMBL19344525 | 0.84 | CNR2 (0.34) | CNR2 | |
| SCHEMBL23584605 | 0.84 | PRMT5 (0.30) | — | |
| SCHEMBL23584604 | 0.83 | — | — | |
| SCHEMBL23584733 | 0.80 | EIF2AK4 (0.34) | GPR119NAMPT | |
| SCHEMBL19344499 | 0.80 | GPR119 (0.37) | GPR119NAMPTBACE1OPRD1OPRK1 | |
| SCHEMBL23584683 | 0.79 | KCNH2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |