Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 5/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584613 | 0.91 | PRMT5 (0.50) | PRMT5CNR2GPR119WDR77BACE1 | |
| SCHEMBL23584660 | 0.90 | GPR119 (0.39) | PRMT5CNR2GPR119NAMPTCNR1 | |
| SCHEMBL19344407 | 0.88 | PRMT5 (0.43) | PRMT5CNR2GPR119NAMPTCNR1 | |
| SCHEMBL23584770 | 0.87 | PRMT5 (0.43) | PRMT5CNR2GPR119NAMPTCNR1 | |
| SCHEMBL23584761 | 0.87 | PRMT5 (0.41) | PRMT5CNR2GPR119NAMPTCNR1 | |
| SCHEMBL19344038 | 0.86 | GPR119 (0.36) | PRMT5GPR119NAMPTWDR77OPRD1 | |
| SCHEMBL23584706 | 0.86 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584704 | 0.85 | GPR119 (0.34) | PRMT5GPR119NAMPTWDR77OPRD1 | |
| SCHEMBL23584762 | 0.85 | CNR2 (0.39) | PRMT5CNR2GPR119CNR1BACE1 | |
| SCHEMBL23584763 | 0.85 | PRMT5 (0.40) | PRMT5CNR2GPR119NAMPTWDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |