Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22435148 | 0.87 | OPRD1 (0.35) | — | |
| SCHEMBL19344032 | 0.87 | OPRD1 (0.35) | — | |
| SCHEMBL19343867 | 0.83 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL22434982 | 0.82 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL23584633 | 0.82 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584679 | 0.73 | PRMT5 (0.55) | PRMT5WDR77 | |
| SCHEMBL19344168 | 0.72 | PRMT5 (0.68) | PRMT5WDR77 | |
| SCHEMBL19344013 | 0.72 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL23584580 | 0.71 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584563 | 0.70 | CNR2 (0.37) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |