Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23019789 | 0.98 | EPHX1 (0.46) | EPHX1USP30ALDH1A1KDM5AEPHX2 | |
| SCHEMBL25021947 | 0.85 | EPHX1 (0.47) | EPHX1USP30ALDH1A1EPHX2MEN1 | |
| SCHEMBL28969019 | 0.85 | EPHX1 (0.47) | EPHX1USP30ALDH1A1EPHX2MEN1 | |
| SCHEMBL29042867 | 0.84 | EPHX1 (0.48) | EPHX1USP30ALDH1A1EPHX2MEN1 | |
| SCHEMBL29042882 | 0.84 | EPHX1 (0.48) | EPHX1USP30ALDH1A1EPHX2MEN1 | |
| SCHEMBL29042866 | 0.84 | EPHX1 (0.48) | EPHX1USP30ALDH1A1EPHX2MEN1 | |
| SCHEMBL13696758 | 0.83 | EPHX1 (0.58) | EPHX1USP30ALDH1A1KDM5AEPHX2 | |
| SCHEMBL28779682 | 0.82 | USP30 (0.48) | EPHX1USP30ALDH1A1MEN1MAPT | |
| SCHEMBL28779683 | 0.82 | USP30 (0.48) | EPHX1USP30ALDH1A1MEN1MAPT | |
| SCHEMBL28779703 | 0.81 | EPHX1 (0.48) | EPHX1USP30ALDH1A1EPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943490-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2022-01-26 | — | — | EP | disclosed |
| EP-3842427-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2021-06-30 | — | — | EP | disclosed |