Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 15/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23585952 | 0.84 | NT5E (0.59) | NT5ELMNATP53 | |
| SCHEMBL15713278 | 0.84 | NT5E (0.49) | NT5ELMNATP53ALDH1A1MAPT | |
| SCHEMBL23585912 | 0.82 | NT5E (0.56) | NT5ELMNATP53ALDH1A1MAPT | |
| SCHEMBL17202646 | 0.81 | NT5E (0.72) | NT5ELMNATP53 | |
| SCHEMBL17202642 | 0.81 | NT5E (0.72) | NT5ELMNATP53 | |
| SCHEMBL26030662 | 0.81 | NT5E (0.43) | NT5ELMNATP53ALDH1A1MAPT | |
| SCHEMBL23585880 | 0.80 | NT5E (0.49) | NT5E | |
| SCHEMBL11959962 | 0.80 | LMNA (0.61) | NT5ELMNATP53ALDH1A1MAPT | |
| SCHEMBL26030330 | 0.80 | LMNA (0.61) | NT5ELMNATP53ALDH1A1MAPT | |
| SCHEMBL15713383 | 0.80 | NT5E (0.46) | NT5ELMNATP53ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134411-B1 | PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2021-06-30 | — | — | EP | disclosed |