Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24854834 | 0.82 | ALDH1A1 (0.48) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL24854255 | 0.82 | ALDH1A1 (0.48) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL17624467 | 0.82 | ALDH1A1 (0.50) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL24378832 | 0.78 | ALDH1A1 (0.52) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL12424325 | 0.78 | ALDH1A1 (0.62) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL24607290 | 0.75 | KDM4E (0.39) | TSHR | |
| SCHEMBL24378835 | 0.75 | ALDH1A1 (0.44) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL152090 | 0.74 | ALDH1A1 (0.80) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL21254486 | 0.74 | ALDH1A1 (0.58) | ALDH1A1PKMPOLBSMN1; SMN2MAPT | |
| SCHEMBL18202994 | 0.74 | ALDH1A1 (0.52) | ALDH1A1PKMPOLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021129820-A1 | SPIRO RING-CONTAINING QUINAZOLINE COMPOUND | 微境生物医药科技(上海)有限公司 | 2021-07-01 | — | — | WO | disclosed |