Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23135134 | 0.89 | KDM4E (0.38) | KDM4ETSHRDRD2DRD3OPRM1 | |
| SCHEMBL24204299 | 0.89 | OPRM1 (0.40) | KDM4ETSHRDRD2DRD3OPRM1 | |
| SCHEMBL21107120 | 0.88 | TSHR (0.41) | KDM4ETSHRDRD2DRD3OPRM1 | |
| SCHEMBL24802215 | 0.87 | OPRM1 (0.39) | KDM4ETSHRDRD2DRD3OPRM1 | |
| SCHEMBL23135137 | 0.87 | DRD2 (0.46) | DRD2DRD3OPRM1OPRL1SIGMAR1 | |
| SCHEMBL21107507 | 0.85 | KDM4E (0.43) | KDM4ETSHRDRD2DRD3SIGMAR1 | |
| SCHEMBL23559981 | 0.84 | TSHR (0.47) | KDM4ETSHRDRD2DRD3OPRM1 | |
| SCHEMBL1753483 | 0.84 | TSHR (0.46) | KDM4ETSHRDRD2DRD3OPRM1 | |
| SCHEMBL24589644 | 0.84 | KDM4E (0.40) | KDM4ETSHRDRD2DRD3SIGMAR1 | |
| SCHEMBL24073328 | 0.82 | TSHR (0.36) | KDM4ETSHRDRD2DRD3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |