Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EIF4A1 | P60842 | 4/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25118630 | 0.91 | DHODH (0.57) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23590075 | 0.90 | DHODH (0.71) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23590149 | 0.88 | DHODH (0.44) | DHODHALDH1A1MEN1KMT2AEIF4A1 | |
| SCHEMBL23590222 | 0.84 | PLA2G2A (0.67) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL29959049 | 0.83 | DHODH (0.59) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23578600 | 0.83 | DHODH (0.59) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23590120 | 0.83 | DHODH (0.79) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23590287 | 0.82 | DHODH (0.57) | DHODHALDH1A1GAAMEN1KMT2A | |
| SCHEMBL26074552 | 0.81 | EIF4A1 (0.50) | DHODHALDH1A1MEN1KMT2AEIF4A1 | |
| SCHEMBL23590113 | 0.81 | DHODH (0.60) | DHODHALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278778-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPΑ THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2021134045-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2021-07-01 | — | — | WO | disclosed |