Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 8/20 | 0.51 |
| ▸ | EPRS1 | P07814 | 2/20 | 0.49 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590236 | 0.90 | DHODH (0.53) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL23590149 | 0.90 | DHODH (0.44) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL23590131 | 0.89 | DHODH (0.46) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL6181595 | 0.86 | ALDH1A1 (0.59) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL23590075 | 0.85 | DHODH (0.71) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL23590078 | 0.83 | KDM4E (0.65) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL26074194 | 0.82 | PLA2G2A (0.55) | ALDH1A1DHODHKDM4E | |
| SCHEMBL23590028 | 0.81 | DHODH (0.62) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL23590225 | 0.81 | KDM4E (0.67) | HIF1AHSD17B10ALDH1A1PTGESALOX5 | |
| SCHEMBL23590240 | 0.81 | DHODH (0.73) | HIF1AHSD17B10ALDH1A1PTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278778-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPΑ THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2021134045-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2021-07-01 | — | — | WO | disclosed |