Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 11/20 | 0.46 |
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
| ▸ | CSF1R | P07333 | 5/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | ARAF | P10398 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356982 | 0.92 | RAF1 (0.46) | ABL1BCRRAF1BRAFCSF1R | |
| SCHEMBL2312566 | 0.91 | CSF1R (0.49) | ABL1BCRRAF1BRAFCSF1R | |
| SCHEMBL2356986 | 0.82 | CSF1R (0.49) | RAF1BRAFCSF1RSRC | |
| SCHEMBL2359009 | 0.81 | EPHB2 (0.53) | ABL1BCRRAF1BRAFCSF1R | |
| SCHEMBL12432625 | 0.81 | RAF1 (0.66) | ABL1BCRRAF1BRAFSRC | |
| SCHEMBL14717831 | 0.80 | CSF1R (0.63) | RAF1BRAFCSF1RDDR1DDR2 | |
| SCHEMBL2357420 | 0.79 | ABL1 (0.51) | ABL1BCRRAF1BRAFCSF1R | |
| SCHEMBL12433866 | 0.79 | CSF1R (0.53) | RAF1BRAFCSF1RDDR1DDR2 | |
| SCHEMBL12433888 | 0.79 | ABL1 (0.57) | ABL1BCRRAF1BRAFCSF1R | |
| SCHEMBL2318397 | 0.77 | CSF1R (0.51) | ABL1RAF1BRAFCSF1RDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |