Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 3/20 | 0.52 |
| ▸ | METAP2 | P50579 | 2/20 | 0.49 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23599206 | 0.89 | MEN1 (0.51) | GPR39METAP2METAP1MEN1NPC1 | |
| SCHEMBL23599173 | 0.87 | HIF1A (0.62) | MEN1NPC1KMT2AHIF1APDE5A | |
| SCHEMBL23598974 | 0.82 | HIF1A (0.48) | METAP2METAP1MEN1NPC1KMT2A | |
| SCHEMBL23598955 | 0.80 | METAP1 (0.59) | METAP2METAP1MEN1NPC1KMT2A | |
| SCHEMBL31336930 | 0.72 | PDE2A (0.65) | GPR39MEN1NPC1KMT2APDE5A | |
| SCHEMBL23579560 | 0.72 | PDE2A (0.65) | GPR39MEN1NPC1KMT2APDE5A | |
| SCHEMBL8042386 | 0.72 | HIF1A (0.84) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8042401 | 0.71 | HIF1A (0.85) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL23598969 | 0.71 | SMN1; SMN2 (0.50) | KMT2AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL28855649 | 0.69 | NPC1 (0.63) | MEN1NPC1KMT2AHIF1APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |