Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23598976 | 0.75 | CA1 (0.67) | MAPTKDM4E | |
| SCHEMBL3639768 | 0.74 | RAD52 (0.82) | BCHEACHEAPPRAD52MAPT | |
| SCHEMBL16579894 | 0.72 | ACHE (0.58) | SMN1; SMN2BCHEACHEAPPRAD52 | |
| SCHEMBL21055813 | 0.71 | ACHE (0.60) | BCHEACHEAPPRAD52MAPT | |
| SCHEMBL23599378 | 0.71 | GPR39 (0.52) | SMN1; SMN2KDM4ELMNAKMT2AHTT | |
| SCHEMBL9350959 | 0.70 | RAD52 (0.66) | SMN1; SMN2BCHEACHEAPPRAD52 | |
| SCHEMBL20118838 | 0.70 | APP (0.52) | SMN1; SMN2APPALDH1A1KMT2AHTT | |
| SCHEMBL23598986 | 0.70 | CA1 (0.58) | — | |
| SCHEMBL23599206 | 0.70 | MEN1 (0.51) | SMN1; SMN2KDM4ELMNAKMT2AHTT | |
| SCHEMBL23599173 | 0.69 | HIF1A (0.62) | SMN1; SMN2MAPTNPSR1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |