Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.49 |
| ▸ | KLK1 | P06870 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23599378 | 0.87 | GPR39 (0.52) | HIF1AKLKB1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL23599206 | 0.87 | MEN1 (0.51) | HIF1ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23598974 | 0.80 | HIF1A (0.48) | HIF1ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8032094 | 0.74 | HIF1A (0.92) | HIF1ASMN1; SMN2 | |
| SCHEMBL8032046 | 0.74 | HIF1A (0.86) | HIF1ASMN1; SMN2 | |
| SCHEMBL23598955 | 0.74 | METAP1 (0.59) | HIF1ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8042401 | 0.73 | HIF1A (0.85) | HIF1ASMN1; SMN2 | |
| SCHEMBL31336958 | 0.73 | BCDIN3D (0.59) | HIF1AKLKB1KLK1F2NPC1 | |
| SCHEMBL23579917 | 0.73 | BCDIN3D (0.59) | HIF1AKLKB1KLK1F2NPC1 | |
| SCHEMBL23579984 | 0.71 | CCNC (0.66) | HIF1AKLKB1KLK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |