Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386465 | 0.84 | AKR1C3 (0.50) | PARP1MAPTTSHRTDP1MEN1 | |
| SCHEMBL21182922 | 0.83 | MEN1 (0.39) | PARP1CYP2C19MAPTTSHRTDP1 | |
| SCHEMBL3794069 | 0.82 | NFE2L2 (0.55) | PARP1CYP2C19MAPTTSHRTDP1 | |
| SCHEMBL3794074 | 0.82 | NFE2L2 (0.55) | PARP1CYP2C19MAPTTSHRTDP1 | |
| SCHEMBL23268276 | 0.82 | KMT2A (0.39) | PARP1CYP2C19MAPTTSHRTDP1 | |
| SCHEMBL6258204 | 0.77 | MEN1 (0.42) | MAPTTSHRTDP1MEN1KMT2A | |
| SCHEMBL24254437 | 0.77 | MEN1 (0.42) | MAPTTSHRTDP1CYP3A4MEN1 | |
| SCHEMBL12907944 | 0.75 | BLM (0.41) | PARP1CYP2C19MAPTTSHRTDP1 | |
| SCHEMBL10479693 | 0.75 | DEGS1 (0.43) | MAPTMEN1KMT2ACES2CES1 | |
| SCHEMBL19141920 | 0.75 | DEGS1 (0.43) | MAPTMEN1KMT2ACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130255-A1 | DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES | UCB Biopharma SRL (BE) | 2021-07-01 | — | — | WO | disclosed |