Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 4/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23578328 | 0.84 | MAT2A (0.35) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL23577357 | 0.83 | FNTA (0.35) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL23601235 | 0.82 | FNTA (0.40) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL30920925 | 0.82 | TP53 (0.39) | MAPTTP53FNTAFNTB | |
| SCHEMBL29909768 | 0.82 | FNTA (0.40) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL23577377 | 0.81 | FNTA (0.34) | MAPTTP53FNTAFNTB | |
| SCHEMBL23601015 | 0.81 | EGFR (0.37) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL31169430 | 0.81 | EGFR (0.37) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL23600473 | 0.81 | FNTA (0.36) | MAPTKDM4ETP53ALDH1A1FNTA | |
| SCHEMBL23601440 | 0.81 | FNTA (0.34) | MAPTKDM4ETP53ALDH1A1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2022-10-13 | — | — | US | disclosed |
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324866-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | DGKG, DGKB, DGKK | MAPT 4206/4885KDM4E 1748/4885TP53 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.