Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23577938 | 0.89 | MAPT (0.33) | MAPTPOLBMAP3K5GAASMN1; SMN2 | |
| SCHEMBL29909214 | 0.89 | MAPT (0.33) | MAPTPOLBMAP3K5GAASMN1; SMN2 | |
| SCHEMBL23601548 | 0.85 | PIK3CD (0.35) | MAPTPIK3CDDHODHCYP17A1CYP1A2 | |
| SCHEMBL23601746 | 0.84 | MAPT (0.38) | MAPTPOLBPIK3CDMAP3K5GAA | |
| SCHEMBL23601255 | 0.83 | MAPT (0.39) | MAPTPOLBPIK3CDTP53HPGD | |
| SCHEMBL23601741 | 0.83 | SMN1; SMN2 (0.32) | MAPTSMN1; SMN2 | |
| SCHEMBL23601843 | 0.83 | MAPT (0.32) | MAPTSMN1; SMN2 | |
| SCHEMBL23577851 | 0.83 | MAP3K14 (0.31) | MAPT | |
| SCHEMBL24721316 | 0.83 | SMN1; SMN2 (0.32) | MAPTSMN1; SMN2 | |
| SCHEMBL29909157 | 0.83 | MAPT (0.32) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |