Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168588 | 0.77 | HTR2C (0.54) | QDPRSIGMAR1HTR2CNAMPT | |
| SCHEMBL31704650 | 0.77 | ATM (0.48) | QDPRSIGMAR1HTR2C | |
| SCHEMBL31705007 | 0.77 | HTR2C (0.54) | QDPRSIGMAR1HTR2CNAMPT | |
| SCHEMBL18715828 | 0.77 | QDPR (0.56) | QDPRSIGMAR1HTR2CALDH1A1KDM4E | |
| SCHEMBL30798421 | 0.75 | QDPR (0.56) | QDPRSIGMAR1HTR2CNAMPTFTO | |
| SCHEMBL29152557 | 0.75 | QDPR (0.56) | QDPRSIGMAR1HTR2CNAMPTFTO | |
| SCHEMBL31705952 | 0.74 | QDPR (0.45) | QDPRSIGMAR1HTR2CNAMPTFTO | |
| SCHEMBL31706748 | 0.73 | QDPR (0.50) | QDPRSIGMAR1HTR2C | |
| SCHEMBL31706054 | 0.73 | QDPR (0.44) | QDPRSIGMAR1HTR2CALDH1A1KDM4E | |
| SCHEMBL31705055 | 0.73 | QDPR (0.44) | QDPRSIGMAR1HTR2CALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133917-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-07-01 | — | — | WO | disclosed |